Crinumin, a novel substitute of chymotrypsin, may control pancreatic insufficiency and inflammation: Purification and characterization

Crinumin, a glycosylated serine protease with chymotrypsin like catalytic specificity was purified from a medicinally important plant _Crinum asiaticum_ of family _Amaryllidaceae_. Ethno-botanical information and Pharmacological studies confirming about the presence of active bio- molecules in the _Crinum_ played crucial role in injury, inflamed joint, local pain and arthritis. Biomedical research suggests chymotrypsin was not only used as digestive aid but also helpful in the above disease. These findings support towards the crinumin may be the active bio-molecule. Crinumin shows activity over a wide range of pH (4.5-11.5 and optimum at 8.5), temperature (75 °C and optimum at 70 °C) and is also functional against chaotrophs, organic solvents, and detergents even after prolonged exposure. The molecular mass (67.7kDa), extinction coefficient (17.7) and isoelectric point (6.9) were also estimated. The denatured natural substrates, such as casein, azocasein, azoalbumin and haemoglobin were hydrolysed by crinumin with very high specific activity. The enzyme also showed amidolytic activity against synthetic substrates, N-succinyl-Phe-p-nitroanilide and α-leucine-pnitroanilide. The apparent Km, Vmax and Kcat values obtained from the Lineweaver–Burk plot were 5 × 104 μM, 0.316 μM/min and 0.73 with N-succinyl-L-phenylalanine-p-nitroanilide as substrate. The proteolytic activity of the enzyme is inhibited by PMSF but not by SBTI make it more special and useful than other serine proteases being used in the food industry. Easy and economic purification with high yield (33%), stability and activity in adverse conditions with chymotrypsin like functioning make it better among known chymotrypsin enzymes from different sources

Girish Karnad’s Hayavadana: Placing the Importance of Mythical Background

As a reader of Karnad's plays, one needs to focus on their sources. Every literary expression has a source and in that the plot is gotten from someplace. The normal wellsprings of his plays incorporate fantasy, cultural story, myths, Puranas, recorded accounts, legends and so forth He appears to have propelled by Shakespeare who follows similar propensity of adjusting perceived plots. Present-day writers will in general utilize unique plots, or any notable recorded or political occasion, or adjust a famous Greek fantasy. There is not anything amiss with the act of adjusting any known or obscure content since it might give you new knowledge into the source text. A few pundits even say that each literary work depends on other writing as it conveys the echoes of its procreator. The activity of discovering how the first messages are adjusted and the new importance produced in the process merits endeavoring; it offers us another viewpoint regarding the matter, occasion, plot and so on

User’s Satisfaction with Library Resources and Services: A Case Study of IIT Libraries in India

This present study is an investigation of user’s satisfaction with library resources and services in IIT libraries in India. A survey research method was adopted to address the research questions. 800 questionnaires were distributed among final year graduate students, postgraduate students, research scholars and faculty members of 7 IIT libraries to collect relevant data regarding their satisfaction. 758 filled-in questionnaires were received and analyzed. On the basis of finding, some suggestions have included in this study to increase user’s satisfaction from librarie

Scurvy induced changes and ascorbate defense in albino rats, Rattus norvegicus

An attempt has been made to find out effectiveness of scorbutogenic diet in albino rats, Rattus norvegicus. These animals received 50 and 80 gm cakes of scorbutogenic diet for 15 and 30 days respectively. No scurvy like symptoms were observed rather boils got appeared on their hind limbs, below ear and neck region. Steroid producing glands indicated enhanced steroidogenesis as evidenced by decreased concentrations of adrenal ascorbate and cholesterol. The results suggested that scorbutogenic diet was ineffective to cause scurvy in this species

Simulation-based Energy and Daylighting Impact Assessment of Integrated Shading Devices and Lighting Controls in Commercial Buildings

Fenestration systems are estimated to be responsible for 1,790 PJ of primary energy consumption annually in commercial buildings in the US and have significant impact on occupants’ visual and thermal comfort. Window shading devices such as shades and blinds are cost-effective means to reduce energy losses/gains from fenestration systems and provide a comfortable environment in the buildings. Besides being cost effective, these products are less intrusive to install when retrofitting the buildings. To maximize the benefits, however, these products require integrated control strategies. Due to complex modeling process involved, existing control strategies used by shade automation industries, generally are not evaluated for energy and daylighting benefits. This paper presents the impacts of shading devices on various aspects of built environment using a comprehensive simulation study. The simulation is performed using a framework enabling automation of daylight and energy simulation and their interaction as well as result post-processing. The results from the simulation show that the control strategies enabled annual cooling and lighting energy savings of up to 40% and 25% respectively. The impact of different shading types, controls and climate conditions on the energy savings results is analyzed. The results of the impact of this technology on energy consumption, daylighting, and occupant comfort from this study will help building owners, designers, engineers, and utilities make informed decisions

Assessment of Research Productivity of Indian School of Business (ISB), Hyderabad, India

This study aimed to perform a scientometric analysis of the Indian School of Business, Hyderabad, from 2002 to 2020. The study has used different scientometric dimensions to evaluate the quantitative growth of research publications. The affiliation search was performed to find out the research publications by using the Scopus database. To make the analysis complete and to get better outcomes, authors have considered total publications produced since the inception of ISB, Hyderabad. This study has analysed the year-wise growth of publications, most preferred sources, authorship pattern, subject-wise distribution of papers, etc. Furthermore, the study also explored international research collaboration. During the study period, the study identified a total of 561 publications and 12029 citations. The study found that 2015 and 2018 are the most productive years with 52 publications. The majority of the papers have appeared under three authorship patterns, and the Degree of Collaboration and Collaborative Coefficient is apparent with a total of 0.90 and 0.57, respectively. The Panel data models with spatially correlated error components published by Kapoor M., Kelejian H.H., Prucha I.R published in the Journal of Econometrics Section is a highly cited (335) paper, and Production and Operations Management is the topmost source for publication

Information Visualization Research Publications during 1990-2018: A Scientometric Analysis

To understand the history and research status of information visualization, information visualization research citation data has been collected from the Scopus expanded during the period from 1990 to 2018. Results indicated that the research of information visualization has increased during the studied 29-year period. The country with the highest research output was the United States with 1996 publications, while the institution with the highest research output was the CNRS Centre National de la Recherche Scientifique. The majority of research articles have been contributed from developed countries. It also revealed that developed countries have more research advantages in comparison to developing countries. The top three outputs journals were Nucleic Acids Research, BMC Bioinformatics and Bioinformatics

Research Trends on Open Science: A Bibliometric Analysis and Visualization

This study examines Open Science research output at a global level from 1989 to 2021. The data was obtained from the Web of Science database. During the study, 1301 records were retrieved. The data was then visualized using VOSviewer software version 1.1.16. The finding revealed that Ross, Joseph S., and Bradley, Jean-Claude were the most prolific authors, with 7 documents. The leading organization on open science research was the MCGILL University, with 25 documents. Furthermore, the United States had supplied 442 documents, followed by England with 169 and Germany with 113. The finding indicates that there was a steady increase in open science research during the study period